188bet金宝博

王静博士，188bet金宝博 教授，博士生导师，医学与健康研究院独立PI。现任188bet金宝博 副院长，河北省创新药物研究与评价重点实验室主任，河北省药品监督管理学会药品检验审评监管专业委员会主任委员，河北省毒理学会常务理事。河北省优秀教师，河北省优秀博士、硕士论文指导教师。研究方向集中于纳米药物共晶和纳米材料的生物应用。主持国家自然科学基金2项、中国博士后基金、河北省“高校百名创新人才”支持计划项目、河北省自然科学基金多项、河北省科技厅重大支撑课题、河北省“生物医药联合基金”和“精准医学联合基金”重点项目等多项课题。获河北省科技进步二等奖一项（第一）、三等奖一项（第一）。以通讯作者在Angew. Chem. Int. Ed，Bioactive Materials, ACS Applied Materials & Interfaces, Food chemistry, Analytical Chemistry, Sensors and Actuators B: Chemical等国内外学术期刊上发表论文多篇。

近5年主持课题：

（1）项目名称：基于线粒体靶向及联合给药策略的化疗-光热“多靶标、多 模式”药物递送体系研究

项目承担人：王静

项目编号：H2020206416

项目类别：河北省生物医药联合基金重点项目

起止年月：2020/09/01-2022/12/31

获资助金额：30万元

（2）项目名称：基于自聚集效应的SERS传感平台构建及精准检测食品和环境中抗生素残留新方法研究

项目承担人：王静

项目编号：82473752

项目类别：国家自然科学基金面上项目

起止年月：2025/01/01-2028/12/31

获资助金额：49万元

（3）项目名称：基于活性代谢产物筛选肾素-血管紧张素-醛固酮/抑制脑啡肽酶双靶点药物及成药性评价

项目承担人：王静

项目编号：246Z2601G

项目类别：河北省科技厅中央引导地方科技发展资金项目

起止年月：2024/05/01-2026/4/30

获资助金额：50万元

（4）项目名称：基于Piezo1信号通路精准调控的智能压电聚合物促进骨折愈合及其机制研究

项目承担人：王静

项目编号：H2025206750

项目类别：河北省精准医学创新发展联合基金重点项目

起止年月：2025/01/01-2027/12/31

获资助金额：50万元

近3年发表通讯作者论文：

2026年：

1.Flexible and microporous porphyrin-confined hydrogel for electrochemiluminescent biosensing application, Sensors and Actuators: B. Chemical, 2026,446, 138678

2025年：

2.Tungstotellurate(VI)-Based Nanocomposite Inhibits Breast Cancer  Proliferation and Metastasis by Enhancing Cuproptosis and Apoptosis, Angew. Chem. Int. Ed. 2025, e202514795

3.A dual-functional polyoxomolybdate@COF nanoplatform for  synergistic chemo-photodynamic tumor therapy, Chinese Chemical Letters, 2025, 111953

4.Metabolomics-driven elucidation of the synergistic therapeutic mechanism of a novel  SGLT-2/PPAR-γ dual receptor supramolecular system for treatment diabetes and obesity, Journal of Pharmaceutical Analysis, 2025, 101308

5.Porphyrin-Decorated Sodium Alginate Hydrogel with Carbon  Nanotubes for Confinement-Enhanced Electrochemiluminescence  and Antibiotic Resistance Gene Detection, Anal.Chem. 2025, 97, 14584−14593

6.Novel nanoceria in situ-derived porphyrin heterostructure enhanced electrochemiluminescent and colorimetric dual-mode detection of tetracycline residue in foods, Food Chemistry, 2025, 485,144459

7.Targeting matrix metalloproteinases activating and indoleamine 2,3-dioxygenase suppression for triple-negative breast cancer multimodal therapy, International Journal of Biological Macromolecules, 2025, 310, 143289

8.Mesoporous silica-coated gold nanorod grafted with cisplatin prodrug on the surface enhances radiotherapy for cervical cancer via triple-strategy approach, Colloids and Surfaces B: Biointerfaces, 2026, 257, 115160. 

2024年：

9.ROS-responsive and triple-synergistic mitochondria-targeted polymer micelles for efficient induction of ICD in tumor therapeutics, Bioactive Materials, 2024, 36, 490–507

10.Engineering a porphyrin COFs encapsulated by hyaluronic acid tumor-targeted nanoplatform for sequential chemo-photodynamic multimodal tumor therapy, International Journal of Biological Macromolecules, 2024, 279, 135328

11.Silver Nanoparticles In Situ Enhanced Electrochemiluminescence of  the Porphyrin Organic Matrix for Highly Sensitive and Rapid  Monitoring of Tetracycline Residues, J. Agric. Food Chem. 2024, 72, 16, 9498–9506

12.Mitochondrial Targeted Thermosensitive Nanocarrier for Near Infrared-Triggered Precise Synergetic Photothermal NitricOxide  Chemotherapy, ACS Appl. Mater. Interfaces, 2024,16,18252−18267 

13.GSH-responsive bithiophene Aza-BODIPY@HMON nanoplatform for  achieving triple-synergistic photoimmunotherapy, Colloids and Surfaces B: Biointerfaces, 2024, 242, 114109

14.Chiral 5-fluorouracil-arginine cocrystals screened by wet powder grinding method: Leading to synergistic anti-tumor and alleviate cardiotoxicity, Powder Technology, 2024, 436, 119487

15.Selective pharmaceutical sensitization design based on amino acid  metabolism: 5-fluorouracil-sarcosine cocrystal prepared by wet powder grinding method, Advanced Powder Technology, 2024, 35, 104514

2023年：

16.Donor-acceptor based enhanced electrochemiluminescence of coumarin microcrystals: Mechanism study and sensing application, Sensors&Actuators:B.Chemica, 2023, l393, 134296

17.Insights into the enhanced electrochemical  sensing behavior of hydroquinone and catechol  simultaneously enabled by ultrafine layer CoP–NiCoP heterostructure on graphene frameworks, Nanoscale, 2023, 15, 9823-9834

18.Multifunctional fluorescent mesoporous carbon nanoprobe for MMP-2-activated cancer cell imaging and targeted photothermal therapy, Analytica Chimica Acta, 2023, 1260, 341203

19.Lipid-functionalized gold nanorods with plug-to-direct mitochondria targeting ligand for synergetic photothermal-chemotherapy of tumor therapy, European Journal of Pharmaceutics and Biopharmaceutics, 2023, 185, 71–81

20.Mitochondria-targeted and multistage synergistic ROS-elevated drug delivery system based on surface decorated MnO2 with CeO2 for enhanced chemodynamic/chemotherapy, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023, 656, 130495

21.Cocrystallization of 5-fluorouracil with gallic acid: A novel 5-fluorouracil cocrystal displaying synergistic anti-tumor activity both in oral and intraperitoneal injection administration, European Journal of Pharmaceutics and Biopharmaceutics, 2023, 187, 12-23